Figure 6 | Cell Death & Disease

Figure 6

From: Bone marrow-derived mesenchymal stem cells ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy

Figure 6

BM-MSCs promoted clearance of dysfunctional mitochondria through enhanced autophagy in chronic HG-treated INS-1 cells. (a) Immunofluorescence analysis was used to determine the number of Mito Red-marked mitochondria colocalized with LC3-labeled autophagosomes. White arrows point at the colocalization. Scale bar, 20 μm. (b) TEM analysis showed that autophagosomes engulfed damaged mitochondria for degradation in INS-1 cells co-cultured with BM-MSCs. White arrows pointed to mitochondria. Scale bar, 0.5 μm. Magnification: × 40 000. All the data were collected from at least three independent experiments

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