Figure 3 | Cell Death & Disease

Figure 3

From: Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines

Figure 3

Synergy between AZD5582 and TRAIL correlates with response to TRAIL monotherapy but not to AZD5582 or TNFα monotherapy. (a) Correlation between TRAIL activity at 30 ng/ml concentration and synergy score of AZD5582/TRAIL combination treatment. (b) Correlation between AZD5582 activity at 10 nM concentration and synergy score of AZD5582/TRAIL combination treatment. (c) Correlation between TNFα activity at 30ng/ml concentration and synergy score of AZD5582/TRAIL combination treatment. (d) Correlation between TNFα activity at 30 ng/ml concentration and synergy score of AZD5582/TNFα combination treatment. Pearson’s correlation coefficient (r) and P-values were calculated for each analysis

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