Table 1 BV6/TMZ treatment upregulates ISGs

From: Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death

Enriched gene set

ES

MOSERLE_IFNA_RESPONSE

0.82

SANA_RESPONSE_TO_IFNG_UP

0.81

BROWNE_INTERFERON_RESPONSIVE_GENES

0.77

DER_IFN_GAMMA_RESPONSE_UP

0.76

REACTOME_INTERFERON_GAMMA_SIGNALING

0.74

REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_ IFN_ALPHA_BETA_PATHWAYS

0.73

BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE

0.72

HECKER_IFNB1_TARGETS

0.71

REACTOME_INTERFERON_ALPHA_BETA_SIGNALING

0.70

DER_IFN_ALPHA_RESPONSE_UP

0.69

DER_IFN_BETA_RESPONSE_UP

0.65

REACTOME_INTERFERON_SIGNALING

0.63

  1. A172 cells stably expressing IκBα-SR or EV were treated for 9 h with 100 μM TMZ and/or 2 μM BV6 or DMSO. Whole-genome expression profiling was performed. Genes with similar regulation in A172 cells expressing IκBα-SR served as control for background expression of non-NF-κB-stimulated genes. GSEA was performed comparing TMZ/BV6-treated cells to all other settings. The enrichment score (ES) of IFN signaling-mediated gene sets out of the top 100 regulated gene sets upon BV6/TMZ treatment are shown. The false discovery rate for all gene sets shown in the table is <0.0. Mean values of three independent experiments are shown
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