Figure 1 | Cell Death & Disease

Figure 1

From: Radiation-induced gamma-synuclein in regards to DC function

Figure 1

Immunosuppressive effect of SNCG. Tumor cells exposed to radiation undergo different types of tumor cell death such as apoptosis, necrosis, mitotic catastrophe, and senescence. The dying tumor cells emitted various surface molecules and cellular components including already known DMAPs, as well as SNCG. SNCG decreased phenotypic maturation ligands of DCs and downregulated pro-inflammatory cytokine production by DCs, thus led to impede T-cell activation. CD, cluster of differentiation; MHC, major histocompatibility complex; imDCs, immature dendritic cells

Back to article page