Figure 8
From: Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101
Schematic diagram summarizing the results. MGRN1-mediated multimonoubiquitination of TSG101 governs fusion between lysosomes and amphisosomes/late endosomes (denoted by red arrows); MGRN1 does not affect fusion between autophagosome and late endosome. Role of MGRN1 in direct fusion between autophagosome and lysosomes remains a possibility. Grey arrows denote pathways where role of MGRN1 is not implicated. Green arrow denotes pathway where role of MGRN1 is unknown
