Figure 4
From: Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth
Morphological and functional defects in the embryos and placentas after genetic modifications. (a–c’, e–g’ and i–k’) Gross appearance of embryos, placentas, yolk sacs at E12.0. (d–d’, h–h’, l–l’ and m–o) The transplacental passage of Rhodamine 123. The pregnant dams were intraperitoneally injected with rhodamine 123 at 1 mg/kg, after 2 h, the living embryos at E12.0 were visualized under a fluorescence stereomicroscope and the fluorescent intensities were determined by spectrophotofluorometer (n=3). *P<0.05 versus respective controls
