Figure 6
Both sc-tPA and tc-tPA rescue neurons from serum deprivation-induced apoptosis. (a) Neuronal death measured after a 24-h exposure to serum deprivation (SD) alone or in the presence of sc-tPA or tc-tPA at 300 nM alone or plus aprotinin (1 μM; mean±S.E.M.; n=3 experiments; *P<0.05). (b and c) Neuronal death measured after a 24-h exposure to SD alone or in the presence of sc-tPA or tc-tPA plus GluN1 antibody (10 μg/ml; b) or AG1478 (5 μM; c) (mean±S.E.M.; n=3 experiments; 4 wells per condition; *P<0.05, NS: not significant, Kruskal–Wallis test followed by Mann–Whitney test)
