Figure 8
tPA-dependent crosstalk between EGFRs and NMDARs. sc-tPA-induced potentiation of NMDAR signaling and subsequent neurotoxicity, inhibited by GluN1 antibody. tPA also promotes EGFR signaling and subsequent antiapoptotic effects, independently of its conformation (sc-tPA and tc-tPA), an effect occurring even at low concentrations (down to 10 nM) and inhibited by AG-1478, an inhibitor of EGFR transphosphorylation. tPA-dependent activation of EGFRs leads to downregulation of NMDAR signaling and subsequent neurotrophic effects
