Figure 2

FasL mediates both photoreceptor apoptosis and necrosis after retinal detachment. (a) BALB/c FasL−/− mice showed significantly less apoptotic and necrotic photoreceptor cell deaths than BALB/c WT mice at 24 h after retinal detachment (P<0.05 each). (b) B6129 ΔCS mice exhibited significantly more apoptotic photoreceptor cell death than B6129 WT mice at 24 h after retinal detachment (P<0.05 each), whereas there was no significant difference in necrotic photoreceptor cell death between them. A, apoptosis; N, necrosis