Figure 3 | Cell Death & Disease

Figure 3

From: Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium

Figure 3

Retinal detachment-induced inflammatory cytokine expression is reduced in FasL−/− mice but increased in ΔCS mice. (a and b) ELISA to detect MCP-1 (a) and IL-6 (b) in the BALB/c WT and BALB/c FasL−/− retinas at 24 h after retinal detachment (n=8 each). MCP-1 generation was significantly suppressed in BALB/c FasL−/− mice (*P<0.05). IL-6 expression was reduced (but not significant) in BALB/c FasL−/− than in BALB/c WT mice. (c and d) ELISA to detect MCP-1 (c) and IL-6 (d) in the B6129 WT and B6129 ΔCS retinas at 24 h after retinal detachment (n=8 each). MCP-1 and IL-6 generation was significantly increased in B6129 ΔCS than in B6129 WT mice (*P<0.05)

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