Figure 5 | Cell Death & Disease

Figure 5

From: Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium

Figure 5

Subretinal injection of soluble Fas ligand attenuates photoreceptor cell death after retinal detachment. (a) TUNEL-positive cell density in the outer nuclear layer (ONL) in B6129 ΔCS mice at 24 h after retinal detachment. Recombinant murine soluble Fas ligand (sFasL) or control phosphate-buffered saline (CTR) was injected into the subretinal space when creating retinal detachment (n=12 each group). The eyes with sFasL showed significantly reduced photoreceptor cell death as compared with control eyes (*P<0.05). (b) TUNEL (green) and TO-PRO-3 (blue) staining at 24 h after retinal detachment. The graphs show mean±S.E.M. Scale bar, 50 μm

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