Figure 6 | Cell Death & Disease

Figure 6

From: Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition

Figure 6

PrPc enables peri-infarct homing of systemically delivered NPCs. (a) Density of GFP+ NPCs in the ischemic striatum, (b) neuronal density in the ischemic striatum revealed by NeuN immunohistochemistry and (c and d) motor coordination deficits evaluated by tight rope and rota rod tests of WT, PrP−/− and PrP+/+ mice exposed to 45 min MCA occlusion followed by 28 days reperfusion. In (c and d), mice received intravenous transplantation of normal saline (control) or adult GFP+ NPCs (106 cells in 300 μl normal saline) 6 h after reperfusion. *Significantly different from WT mice not receiving NPC treatment, P<0.05. #Significantly different from corresponding PrP−/− or PrP+/+ mice, P<0.05

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