Figure 1 | Cell Death & Disease

Figure 1

From: P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development

Figure 1

Loss of function of p53 in undifferentiated MSCs and origin of OS. Preosteoblasts and osteoblasts can be considered as cells of origin for OS development (2) as well as undifferentiated MSCs (1). When mesenchymal progenitor cells (1) or preosteoblast cells (2) become aberrant following mutational events of p53 tumor suppressor gene (*p53), they show compromised growth, proliferation and terminal differentiation. The arrow (*) indicates MSCs with loss of function of p53: *MSCs

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