Figure 3
From: P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development
Loss of function of p53 compromises proliferation and differentiation of MSCs. MSCs can be isolated from adult organs, such as bone marrow, skeletal muscle, adipose tissue, and others, with a higher prevalence from the bone marrow (BM). MSCs can be identified in vitro for their surface markers and their multipotential differentiation properties. P53 has a role in regulating growth and proliferation of MSCs. Mutational events of p53 or p53 deficiency compromise the proliferation rate of MSCs mainly through p21 or CDK inhibitor p21Cip1/Waf1
