Figure 4
From: P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development
P53 is a negative regulator of differentiation pathways of MSCs. P53 can negatively regulate differentiation of mesenchymal progenitor cells such as osteogenesis, myogenesis, adipogenesis, and neurogenesis pathways by downregulating the expression levels of key transcription factor genes. In undifferentiated MSCs, p53 maintains lower expression levels of key transcription factor genes involved in the early phases of differentiation, such as Osterix and Runx2 for osteogenesis, PPAR-γ, CEBP-α for adipogenesis, Rb for myogenesis, and PTEN for neurogenesis. P53 status exerts a decisive role on proliferation, commitment, differentiation, and maturation of MSCs
