Table 1 Characteristics of patients and derived primograft leukemia samples
N | % | |
|---|---|---|
Total | 40 | 100 |
Primograft derived from | ||
Initial diagnosis | 37 | 93 |
Relapse | 3 | 7 |
Gender | ||
Male | 23 | 58 |
Female | 17 | 42 |
Age (years) | ||
1–9 | 27 | 68 |
<1 or >9 | 13 | 32 |
Immunophenotype | ||
Pro-B ALL | 4 | 10 |
c-ALL | 26 | 65 |
Pre-B ALL | 10 | 25 |
Gene alterations | ||
ETV6/RUNX1 | 7 | 17 |
BCR/ABL | 1 | 3 |
MLL-rearrangement | 4 | 10 |
None of the above | 28 | 70 |
BFM high risk | ||
Yes | 5 | 13 |
No | 32 | 80 |
Not applicable | 3 | 7 |
Prednisone response | ||
Poor | 1 | 3 |
Good | 36 | 90 |
Not applicable | 3 | 7 |
Resistance to spontaneous apoptosis | ||
Yes | 5 | 13 |
No | 11 | 27 |
Not analyzed | 24 | 60 |
Time to leukmia (TTL) | ||
Short | 11 | 27 |
Long | 29 | 73 |