Table 1 Characteristics of patients and derived primograft leukemia samples

From: Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia

 

N

%

Total

40

100

Primograft derived from

 Initial diagnosis

37

93

 Relapse

3

7

Gender

 Male

23

58

 Female

17

42

Age (years)

 1–9

27

68

 <1 or >9

13

32

Immunophenotype

 Pro-B ALL

4

10

 c-ALL

26

65

 Pre-B ALL

10

25

Gene alterations

ETV6/RUNX1

7

17

BCR/ABL

1

3

MLL-rearrangement

4

10

 None of the above

28

70

BFM high risk

 Yes

5

13

 No

32

80

 Not applicable

3

7

Prednisone response

 Poor

1

3

 Good

36

90

 Not applicable

3

7

Resistance to spontaneous apoptosis

 Yes

5

13

 No

11

27

 Not analyzed

24

60

Time to leukmia (TTL)

 Short

11

27

 Long

29

73