Figure 3
Properties of Big Dyn-induced current surges in DRG neurons. (a) Current surges across the plasma membrane recorded in control cells (gray) and induced by incubation with 100 nM Big Dyn (blue trace) or 1 μM of Big Dyn (orange race). (b) All-point histograms for the holding currents as shown in (a). (c) Power-law decay measured in the power spectrum (S(f)~1/fβ) of basal transmembrane current noise. Under control conditions, the power-law decaying power spectra close to 1/f was observed (gray trace). In response to Big Dyn, the power spectrum tended towards Brownian noise spectra, characterized by larger decay exponents β (orange and blue traces). (d) Self-affinity of a signal calculated by DFA expressed as log–log plot F(L) vs L, shows crossovers indicated by arrows in both control conditions and under Big Dyn. All measurements were conducted on DRG neurons clamped at −100 mV
