Table 1 Mouse islets perfused with Tpl2-I are protected against the cytokine-induced loss of intracellular calcium concentration ([Ca2+]c) changes in response to glucose

From: Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4

 

Control

CK

Tpl2-I

−

+

−

+

Frequency (min−1)

0.467±0.054

0.500±0.065a

No

No

Response to glucose

22/22 (100%)

18/18 (100%)

7/17 (41.2%)

20/23 (87%)

Mean [Ca2+]c level (a.u.)

 3 mM glucose

0.831±0.005

0.798±0.004b

0.908±0.004b

0.909±0.006b

 15 mM glucose

0.972±0.013

0.959±0.019a

0.948±0.006c

0.972±0.006a,d

 Delta response

0.142±0.013

0.161±0.020a

0.040±0.005b

0.064±0.006b,d

  1. a.u., arbitrary unit, Tpl2-I, Tpl2 inhibitor, CK, cytokines
  2. aNS compared with Control without Tpl2-I
  3. bP<0.001 compared with Control without Tpl2-I
  4. cP<0.05 compared with Control without Tpl2-I
  5. dP<0.01 compared with Cytokines without Tpl2-I
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