Figure 6 | Cell Death & Disease

Figure 6

From: Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation

Figure 6

Proposed sequence of the downstream pathways activated during dengue infection. Our data suggest this sequence of stress (ATM, ER and ROS) and homeostatic (macro) autophagy pathways are activated during various stages of dengue infection. In this diagram, we highlight the different marker proteins (and associated events) we have examined in this study. The circled n signifies that the number of steps and components involved in this step of our model is still unknown. Virus infection activates autophagy by activating ATM that releases the mTORC1-derived inhibition of autophagosome formation and triggers the PERK-based ER stress pathway, furthering turnover of autophagosomes. Increase in ROS occurs late and does not participate in the protection of the cells

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