Figure 4 | Cell Death & Disease

Figure 4

From: MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway

Figure 4

HBx expression correlates with IGF2BP2 expression. (a) With the downregulation of miR-216b expression in 50 tumor tissues, the HBx expression and IGF2BP2 expression are increased. (Protein expression was evaluated by IPP6.0). (b) The HBx and IGF2BP2 expression are upregulated the same time in HCC tumor tissues than in adjacent liver tissues (A, adjacent liver; T, tumor tissue). (c) IGF2BP2 expression is significant higher in HCC tumor tissues with high HBx expression (A1, adjacent liver 1; T1, tumor tissue 1) than in adjacent liver in IHC assay. (d) The overexpression of HBx could obviously downregulate the expression of miR-216b in HepG2 cells (P<0.01). (e) When miR-216b expression is upregulated, the HBx upregulating effects on IGF2BP2 expression and the following pathways are offset. (f) When miR-216b expression is downregulated, the siHBx downregulating effects on IGF2BP2 expression and the following pathways are offset

Back to article page