Table 1 The somatic mutations of SPOP identified in exome sequencing of endometrial cancers
Amino-acid change | Mutation types | Histological subtypes | ratios | Reference | |
|---|---|---|---|---|---|
1 | G75R | Missense | Serous | 10% (1/10) | Kuhn E et al.6 |
2 | M117V D140G | Missense | Serous | 5.9% (2/34) | Zhao S et al.5 |
3 | E47K S80R P94A M117I R121Q | Missense | Serous Clear cell | 8% (4/52) 9% (2/23) | Le Gallo M et al.7 |
4 | E50K M117I R121Q D140G | Missense | Endometrioid Serous | 5.7% (10/175) 7% (3/43) | Kandoth C et al.4 |
