Table 2 Cbx4 expression is positively correlated with histological grading and metastasis of HCC
Variables | Cases | Cbx4 expression, cases (%) | χ 2 | P -value | |
|---|---|---|---|---|---|
Low | High | ||||
Total | 727 | 263 (100) | 464 (100) | ||
Gender | 0.450 | 0.502 | |||
Female | 88 (12.1) | 29 (11.0) | 59 (12.7) | ||
Male | 639 (87.9) | 234 (89.0) | 405 (87.3) | ||
Race | 0.407 | 0.524 | |||
Han | 478 (65.7) | 169 (64.3) | 309 (66.6) | ||
Minority | 249 (34.3) | 94 (35.7) | 155 (33.4) | ||
HBsAg | 0.516 | 0.473 | |||
Negative | 91 (12.5) | 36 (13.7) | 55 (11.9) | ||
Positive | 636 (87.5) | 227 (86.3) | 409 (88.1) | ||
Anti-HCV | 3.538 | 0.060 | |||
Negative | 725 (99.7) | 261 (99.2) | 464 (100) | ||
Positive | 2 (0.3) | 2 (0.8) | 0 (0) | ||
Hepatocirrhosis | 0.007 | 0. 932 | |||
No | 181 (24.9) | 65 (24.7) | 116 (25.0) | ||
Yes | 546 (75.1) | 198 (75.3) | 348 (75.0) | ||
Smoke | 0.108 | 0.743 | |||
No | 545 (75.0) | 199 (75.7) | 346 (74.6) | ||
Yes | 182 (25.0) | 64 (24.3) | 118 (25.4) | ||
Drink | 0.058 | 0.809 | |||
No | 577 (79.4) | 210 (79.8) | 367 (79.1) | ||
Yes | 150 (20.6) | 53 (20.2) | 97 (20.9) | ||
Tumor size (cm) | 1.688 | 0.194 | |||
≤5 | 171 (23.5) | 69 (26.2) | 102 (22.0) | ||
>5 | 556 (76.5) | 194 (73.8) | 362 (78.0) | ||
Tumor number | 1.083 | 0.298 | |||
Single | 545 (75.0) | 203 (77.2) | 342 (73.7) | ||
Multiple | 182 (25.0) | 60 (22.8) | 122 (26.3) | ||
AFP (ng/ml) | 0.297 | 0.586 | |||
<25 | 311 (42.8) | 116 (44.1) | 195 (42.0) | ||
≥25 | 416 (57.2) | 147 (55.9) | 269 (58.0) | ||
Histological grading | 4.045 | 0.044 | |||
Low | 340 (46.8) | 136 (51.7) | 204 (44.0) | ||
High | 387 (53.2) | 127 (48.3) | 260 (56.0) | ||
Hematogenous metastasis | 10.413 | 0.001 | |||
Absent | 157 (21.6) | 74 (28.1) | 83 (17.9) | ||
Present | 570 (78.4) | 189 (71.9) | 381 (82.1) | ||
Distant metastasis | 4.167 | 0.041 | |||
No | 692 (95.2) | 256 (97.3) | 436 (94.0) | ||
Yes | 35 (4.8) | 7 (2.7) | 28 (6.0) | ||
MVD | 207.745 | 4.3 × 10−47 | |||
≤50 | 261 (36.0) | 184 (70.0) | 77 (16.6) | ||
>50 | 465 (64.0) | 79 (30.0) | 387 (83.4) | ||
TNM stage | 17.895 | 1.3 × 10−4 | |||
I–II | 138 (19.0) | 71 (27.0) | 67 (14.4) | ||
III | 518 (71.3) | 172 (65.4) | 346 (74.6) | ||
IV | 71 (9.8) | 20 (7.6) | 51 (11.0) | ||
