Figure 1 | Cell Death & Disease

Figure 1

From: Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis

Figure 1

miRNA expression dysregulation occurs upon acute and sustained DOX treatment. (a) Experimental design of the models of study included in the miRNA profiling. DOX-induced HF in vivo model was generated by six i.p. DOX injections (2.5 mg/kg) spread over a fortnight. MI was induced by proximal LAD coronary artery ligation. For acute DOX treatment, cultured viable ARVCM were treated with 1 μmol/l for 6 h. For all three models, RNA was isolated specifically from viable ARVCM. (b) Venn diagram showing significantly altered miRNA expression (>1.5-folds, P<0.05) detected for the profiled models of cardiac injury (n=3 per group). The three downregulated members of the miR-30 family are highlighted in yellow. Several other miRNAs have previously been linked to heart disease when dysregulated in the same direction as we observed and appear in bold writing. (c) miRNAs that presented reduced expression levels in at least two experimental models. rno, rattus norvegicus.

Back to article page