Figure 4 | Cell Death & Disease

Figure 4

From: Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis

Figure 4

miR-30 effects on cAMP accumulation and contractility. (a) cAMP accumulation data expressed as % of the respective control samples. Values are the mean±S.E.M. of three independent experiments. The diagram on the right shows the contribution to cAMP production of the three miR-30 targets involved in the β-adrenergic pathway. (b) Baseline % of contraction amplitude of paced ARVCM transfected with either pre-30e or pre-NC for 48 h (100 nmol/l), measured using IonOptix (n=8–10 cells from 6 preparations; t-test; ns, not significant). (c) Contractile responses of isoproterenol-stimulated transfected ARVCM, recorded using IonOptix (n=6 cells from 6 preparations, F-test)

Back to article page