Figure 7
Synergistic tumoricidal acticity of CnB and IFN-γ in a mouse melanoma lung metastasis model. (a–d) Therapeutic effect of CnB and IFN-γ. Nine mice for each group. (a) Representative isolated lungs. (b) Mean melanoma colony numbers in the lungs per mouse. (c) Body weights before and after drug treatments. (d) Quantitative PCR analysis of IL-12, CXCL9, and CD206 genes’ expression in TAMs. Data are a representative result of three mice. (e) Prophylactic effect of CnB and IFN-γ. Ten mice for each group. Survival following tumor challenge was recorded. Statistical differences between treatment groups were calculated by t-test (Graph b–d) and Gehan–Breslow–Wilcoxon test (Graph e). *P<0.05, **P<0.01, ***P<0.001, NS: no significant differences
