Figure 6 | Cell Death & Disease

Figure 6

From: Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1

Figure 6

Inhibition of HDAC1 rescued the decrease of bone formation in vivo. (a) Representative microCT reconstructive images of tibial plateau in WB, HU, and HU+HDAC1 inhibitor mice. n=6. (b) Three-dimensional microstructural parameters of tibial plateau in WB, HU, and HU+HDAC1 inhibitor mice. (c) Representative images showing new bone formation assessed by double calcein labeling in each group. n=4. Scale bars, 50 μm. (d) Histomorphometric analysis of bone formation–related parameters (Ob.S/BS, MAR, BFR, and N.Ob/B.Pm) in WB, HU, and HU+HDAC1 inhibitor mice. (e) Representative hematoxylin–eosin staining images of tibial plateau showing bone volume in each group. n=6. (f) Schematic diagram of the role of HDAC1 in regulating MSC differentiation and bone formation under mechanical stimulation. Data were mean±S.D., *P<0.01. All P-values are based on Student's t-test

Back to article page