Figure 8 | Cell Death & Disease

Figure 8

From: SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways

Figure 8

SP6616 regulates Erk1/2 and Akt signaling in vivo. (a) Pancreatic islet tissue extracts from HFD/STZ mice after SP6616 (50 mg/kg/day) treatment for 5 weeks were analyzed by western blot using the corresponding antibodies (n=3). (b) Relative protein levels in a. (c) Pancreatic islet tissue extracts from db/db mice after SP6616 (50 mg/kg/day) treatment were analyzed by western blot (n=3). (d) Relative protein levels in c. (e) A proposed model interpreting the involvement of PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways in the SP6616-mediated β-cell protection. All data were presented as means±S.E.M. (*P<0.05, **P<0.01)

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