Figure 5
From: Knockdown of linc-UFC1 suppresses proliferation and induces apoptosis of colorectal cancer
The involvement of the WNT/β-catenin pathway induced by linc-UFC1 knockdown. (a and b) Expression levels of β-catenin and its downstream effectors (Myc, MMP-7 and Axin2) were analyzed by western blots using LOVO and SW480 cells with linc-UFC1 knockdown (n=6; *P<0.05 versus NC). (c) The β-catenin mRNA levels were plotted against linc-UFC1 expression in 65 CRC specimens, and a significant positive correlation was obtained (two-tailed Pearson’s correlation, r=0.706; P<0.01). (d) The localization of β-catenin was distributed in both the nucleus and the cytoplasm in the samples with high linc-UFC1 expression and primarily in the cytoplasm in the samples with low linc-UFC1 expression. The images were taken at × 200
