Figure 2 | Cell Death & Disease

Figure 2

From: Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

Figure 2

Metabolic pathway of aerobic glycolysis, FAS and FAO. CPTI can be inhibited directly by ACC2-generated malony-CoA, a crucial intermediate in FAS. This effect prevents FAS and FAO from being activated simultaneously. FAO also takes the long-chain fatty acids as raw materials, which are the products of FAS. FAO and aerobic glycolysis are both significant energy-supplying processes in cancer. Acetyl-CoA generated from FAO serves as an essential source of tricarboxylic acid cycle (TCA), which can finally produce malate to supplement pyruvate

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