Table 1 Overview of CPTI roles in cancer biology
From: Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer
CPTI isoform | Cancer type | Significance | Reference |
|---|---|---|---|
CPTIA | Prostate cancer | Upregulated expression; its inhibition has antitumor actions | |
|  | Burkitt’s lymphoma | Upregulated expression | |
| Â | Glioblastoma | Upregulated expression | |
| Â | Lymphocytic leukemia | Its inhibition has antitumor actions; contributes to cancer chemoresistance | |
| Â | Breast cancer | Upregulated expression; its inhibition has antitumor actions; acts as a new role in the histonic acetylation level of tumor | |
| Â | Gastric cancer | Oleic acid activates its expression | |
| Â | Ovarian cancer | Upregulated expression | |
| Â | Alveolar rhabdomyosarcoma | Contributes to cancer cell motility | |
| Â | Teratocarcinoma | Transcriptional regulation of it by RXR-NR4A receptor | |
| Â | Endothelial cells | Upregulated expression; contributes to tumor neovascularization | |
CPTIC | Lung cancer | Upregulated expression contributes to cancer chemoresistance | |
| Â | Colon | Its inhibition has antitumor actions | |
| Â | Breast | Upregulated expression | |
| Â | Glioblastoma | Upregulated expression | |
CPTI (unspecified isoform) | Hepatoma | Upregulated expression | |
| Â | Acute myeloid leukemia | Its inhibition has antitumor actions | |
| Â | Diffuse large B-cell lymphoma | Upregulated expression | |
| Â | Myeloma | Its inhibition has antitumor actions | |
| Â | Lung cancer | Contributes to cancer chemoresistance |
