Figure 8
Schematic representation of miR-155 regulating the macrophage phenotype transition in skeletal muscle regeneration following injury. Following acute muscle injury, the early stage of muscle repair is characterized by the initial infiltration of neutrophils and monocytes, followed by the activation of pro-inflammatory macrophages, which coincides with the activation of quiescent satellite cells and their subsequent proliferation. As muscle repair proceeds, activation of miR-155 expression releases the SOCS1-mediated inhibition of Jak-STAT signaling, accompanied by a shift to anti-inflammatory macrophages. In the absence of miR-155, SOCS1 levels are elevated, thus dampening the Jak-STAT signaling that is critical for the balance of pro- and anti-inflammatory immune responses
