Figure 6
From: Bax/Bak activation in the absence of Bid, Bim, Puma, and p53
The Linear Model for Bax/Bak activation during apoptosis. In this model, the primary targets of BH3-only proteins are Bcl-xL and Mcl-1, whose primary function is to suppress Bax/Bak activation. Following apoptotic stimulation, the activated BH3-only proteins neutralize/inactivate both Bcl-xL and Mcl-1, allowing Bax and Bak to become activated without the direct activation by BH3-only proteins and p53
