Figure 6
Antitumor activity in ZR-75-30 tumor-bearing mice. Nude mice were injected s.c. with 1 × 106 ZR-75-30 human breast carcinoma cells. Treatment was initiated when tumors reached 100–150 mm3. Tumor growth suppression by sTR, FA1FT and HA5ST administered by daily injections (i.p.) from days 1 to 8, (a) 0.1 nmol per mouse and (b) 1 nmol per mouse. (c) Local treatment strategy. Treatment was initiated when tumors reached 200–250 mm3; 0.5 nmol of FA1FT and sTR were injected daily (days 1–8) in an area close to the established tumors. Statistical analysis was carried out with unpaired t-test, two-tailed test, **P<0.01, ***P<0.001
