Figure 4
From: ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose
ZnCl2 cotreatment restores the ADR-induced JNK phosphorylation inhibited by HG condition. Western blotting (upper panel) and relative quantification (lower panel) of p-JNK/tot-JNK ratio in RKO and HCT116 cells treated with ADR (2 μg/ml) in low and high glucose condition with or without ZnCl2 (100 μM) for 24 h. Anti-β-actin was used as protein loading control. The predicted molecular weight is indicated (kDa). Data of relative quantification of p-JNK/tot-JNK ratio (lower panel) are presented as mean±S.E.M. (n=6) (one-way ANOVA plus Bonferroni test, *P<0.001 ADR versus Mock, ADR/HG versus ADR, ADR/HG/ZnCl2 versus ADR/HG, not statistically significant (NSS) ADR/ZnCl2 versus ADR)
