Figure 2 | Cell Death & Disease

Figure 2

From: Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion

Figure 2

GSIS and mitochondrial function in si-Jph3 islets. (a) Jph3 silencing efficiency. (b) GSIS in response to high and low levels of glucose. (c) Intracellular ATP generation in the presence of glucose. (d) IP3-evoked [Ca2+]m transients amplitude in permeabilized islets. Data are means±S.D. n=3 mice per group, with the minimum 30 islets for GSIS or 20 islets for ATP per mouse. *P<0.05, **P<0.01 versus si-Ctr. ++P<0.01 versus 27.7 mmol/L glucose. (e) Global ΔΨm in islets. Bar=10 μm

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