Figure 6

Ca²⁺ influx and ER stress or Bcl-2/Bax-related proteins in si-Jph3 islets. Unchanged expression of Ca²⁺ influx-related proteins (a), colocalization areas (b), ER stress protein (c) Bcl-2/Bax ratio (d). n=3. (e) Schematic representation of the mechanism of JPH3-dependent GSIS in mouse beta cells