Figure 1
From: Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease
Caspase-2-deficient mice are protected from diet-induced obesity. (a) Right panel: weight increase in caspase-2 knockout and WT mice-fed chow versus Western diet (four animals per genotype in chow diet groups and eight animals per genotype in Western diet groups), at the end of treatment as compared with baseline measurements. Left panel: body mass weight. (b) Body mass % fat (DXA) and epididymal fat weight. (c) Food efficiency (weeks 2–15 of treatment); food and high-corn syrup equivalent ingested during treatment. The errors reported represent mean±S.E.M. *P<0.05, **P<0.01 chow versus Western diet; #P<0.05, ##P<0.01 WT versus knockout mice. Interaction, assessed by two-way ANOVA, indicates that the effect of diet was different between genotypes
