Figure 2
From: Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease
Caspase-2-deficient mice are protected from diet-induced diabetes mellitus and dyslipidemia. (a) Right panel: glucose tolerance test after 15 weeks on diet (AUROC, area under receiver operating characteristic curve, Western diet WT versus knockout mice: 190 versus 122, P=0.02). All animals were evaluated (four animals per genotype in chow diet groups and eight animals per genotype in Western diet groups). Left panel: insulin tolerance test at 15 weeks on diet (AUROC 167 versus 118, P=0.0002). (b) Fasting glucose, insulin and HOMA. (c) Size and area of pancreatic Langherhans islands. (d) Representative H&E sections (200x field) from pancreas. Scale bar, 100 μm. (e) Total cholesterol, triglycerides and nonesterified fatty acids serum levels. The errors reported represent mean±S.E.M. *P<0.05, **P<0.01 chow versus Western diet; #P<0.05, ##P<0.01 WT versus knockout mice. Interaction, assessed by two-way ANOVA, indicates that the effect of diet was different between genotypes
