Figure 5
From: Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease
Caspase-2-deficient mice are protected from NAFLD. (a) Liver weight, liver-to-body weight ratio, % of liver fat (DXA) and liver triglyceride content. (b) Representative photos from oil red staining of liver sections. Scale bar, 100 μm. (c) qRT-PCR analysis of liver RNA for genes involved in lipid metabolism, normalized to chow-diet-fed WT mice. All animals were evaluated (four animals per genotype in chow diet groups and eight animals per genotype in Western diet groups). The errors reported represent mean±S.E.M. *P<0.05, **P<0.01 chow versus Western diet; #P<0.05, ##P<0.01 WT versus knockout mice. Interaction, assessed by two-way ANOVA, indicates that the effect of diet was different between genotypes
