Figure 8 | Cell Death & Disease

Figure 8

From: Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models

Figure 8

Status of ROS and apoptosis in germ and Sertoli cells from 8-week-old and 8-month-old Gpr177 testes. (a) ROS level in germ cells from control, Gpr177 cKO testes at 8 weeks. (b) ROS level in Sertoli cells from control, Gpr177 cKO testes at 8 weeks. (c) ROS level in germ cells from 8-week-old and 8-month-old germ cell-specific Gpr177 knockout testes. (d) ROS level in Sertoli cells from 8-week-old and 8-month-old Gpr177flox/flox, Amh-Cre knockout testes. (e) Flow cytometric analysis of Caspase 3 activity in germ cells from control, Gpr177 cKO testes at 8 weeks. (f) Caspase 3 activity in Sertoli cells from control, Gpr177 cKO testes at 8 weeks. (g) Caspase 3 activity in germ cells from 8-week-old and 8-month-old germ cell-specific Gpr177 knockout testes. (h) Caspase 3 activity in Sertoli cells from 8-week-old and 8-month-old Gpr177flox/flox, Amh-Cre knockout testes. The data are expressed as the mean±S.E.M. *P<0.05

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