Figure 7 | Cell Death & Disease

Figure 7

From: MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

Figure 7

Sensitivity of B cells to highly specific BH3-mimetics that target BCL-XL, BCL-2 or MCL-1. Response of diverse freshly isolated mouse B-cell subsets to (a) the BCL-XL-selective BH3-mimetic A-1155463, (b) the BCL-2-selective BH3-mimetic ABT-199 or (c) the MCL-1-selective BH3-mimetic A-1210477. Data represent cells from the spleen or bone marrow of six individual mice

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