Figure 3
From: MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a
Overexpression of miR-182 significantly reduced cisplatin-induced hair cell apoptosis. (a–c) Caspase 3 (+) cells in the white-dashed-line box are considered caspase 3 (+) hair cells. Caspase 3 (+) and Myo 7a (+) double-labeled cells (hair cells undergoing apoptosis) are indicated by white arrowheads (a, b). Numbers of apoptotic hair cells at the apex, mid, and base turn in the control group, miR-182 OE group, and z-VAD-fmk group (c). Data are shown as means±S.E. Student’s t-test, **P<0.01. Scale bar in bottom-right corner: 20 μm
