Figure 3
miR-150 inhibits leukemia growth in a xenograft murine model. (a) Tumor volumes at the indicated days during the experiment for miR-150 and control groups (n=8 per group). (b) Tumor weights of control and miR-150-overexpressing mice groups. *P<0.05. (c) Tumor sizes at the end of the experiment (day 34). (d) The experimental design of the xenografted mice treated with miR-150 or scrambled oligonucleotides. (e) Tumor volumes at the indicated days with miR-150 or scrambled oligonucleotide injection and the non-treatment control group (n=8 per group). (f) Tumor weights of each group at the end of experiment. ***P<0.001; #, no significance. (g) Tumor sizes after miR-150 or scrambled oligonucleotides treatment. (h) Tumor tissue histology of sections obtained from tumor-bearing mice with different treatments. Tumor morphology was analyzed by hematoxylin and eosin, cell proliferation by Ki67 staining, and apoptosis by TUNEL assay. Scale bar, 20 μm. The results of one mouse from each group were shown
