Table 1 Functional annotation of miR-150-targeted genes

From: miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways

Functional annotation	Target gene	%^a	P-value
GO category
Small-molecule metabolic process	POM121, PISD, STX1A, AMD1, PRKCA, NDST1, ACSL4	16.67	0.001
Fibroblast growth factor receptor signaling pathway	FOXO4, PRKCA, NDST1	7.14	0.001
Positive regulation of transcription from RNA polymerase II promoter	FOXO4, IKZF1, TET3, NFIC, RUNX1	11.9	0.002
Regulation of translational initiation	EIF4B, CTIF	4.76	0.002
Epidermal growth factor receptor signaling pathway	GRB7, FOXO4, PRKCA	7.14	0.003
Polysaccharide biosynthetic process	NDST1	2.38	0.004
S-adenosylmethioninamine biosynthetic process	AMD1	2.38	0.004
Negative regulation of prostaglandin secretion	ACSL4	2.38	0.004
Forward locomotion	TTN	2.38	0.004
DNA demethylation of male pronucleus	TET3	2.38	0.004
Positive regulation of neutrophil differentiation	IKZF1	2.38	0.004
Regulation of vasculature	FZD4	2.38	0.004
Alpha-tubulin acetylation	ATAT1	2.38	0.004
Positive regulation of dense core granule biogenesis	PRKCA	2.38	0.004
In utero embryonic development	TTN, RUNX1, TANC2	7.14	0.004
mRNA transport	POM121, POM121C	4.76	0.005
Forebrain development	NDST1, IKZF1	4.76	0.006
Histone H3-T6 phosphorylation	PRKCA	2.38	0.008
Progesterone secretion	FZD4	2.38	0.008
Positive regulation of Golgi to plasma membrane protein transport	CNST	2.38	0.008
RNA metabolic process	EIF4B, PRKCA, PDCD4	7.14	0.008
Neurotrophin TRK receptor signaling pathway	PRKCA, ARHGEF2, FOXO4	7.14	0.009
Positive regulation of angiogenesis	PRKCA, RUNX1	4.76	0.011
Apoptotic signaling pathway	PRKCA, ARHGEF2	4.76	0.016
Pathway
Proteoglycans in cancer	PDCD4, PRKCA, FZD4, EIF4B	9.52	0.0002
RNA transport	POM121C, POM121, EIF4B	7.14	0.002
Pathogenic Escherichia coli infection	ARHGEF2, PRKCA	4.76	0.005
mTOR signaling pathway	PRKCA, EIF4B	4.76	0.006
Amphetamine addiction	PRKCA, STX1A	4.76	0.008
Insulin secretion	PRKCA, STX1A	4.76	0.012
Pathways in cancer	FZD4, RUNX1, PRKCA	7.14	0.015
Melanogenesis	FZD4, PRKCA	4.76	0.017
Wnt signaling pathway	FZD4, PRKCA	4.76	0.033

^aFrom total 42.

Back to article page

Table 1 Functional annotation of miR-150-targeted genes

Search

Quick links