Figure 3 | Cell Death & Disease

Figure 3

From: Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance

Figure 3

Effects of p53 activation by the MDM2 inhibitor nutlin-3 on the YM155-induced effects on neuroblastoma cell viability. (a) Effects of nutlin-3 (1 μM), YM155 (0.625 nM), or their combination on neuroblastoma cell viability as indicated by MTT assay after 120 h incubation. *P<0.05 relative to either single treatment; n.d.=no detectable cell viability; (b) Representative western blots indicating the effects of combined YM155 and nutlin-3 treatment on p53 signaling (p53 and p21 levels), DNA damage (γH2AX levels), and survivin levels in UKF-NB-3 and UKF-NB-6 cells after 24 h of incubation. The respective quantitative data are provided in Supplementary Figure 3

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