Table 1 Genes upregulated in ZIKV-infected hNPCs and in mouse models of severe microcephaly significantly overlap with P53-related data sets

From: ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53

MSigDB se

Zika

CMV

CitK−/−

Magoh+/−

Elp3−/−

AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53

2.36E−06

    

AMUNDSON_DNA_DAMAGE_RESPONSE_TP53

1.16E−06

 

2.95E−06

5.58E−06

5.57E−04

BIOCARTA_P53_PATHWAY

1.20E−03

 

6.20E−03

8.57E−04

 

BIOCARTA_P53HYPOXIA_PATHWAY

1.50E−03

  

1.44E−03

 

BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A

1.00E−35

 

5.29E−07

 

2.69E−04

BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B

5.65E−26

3.33E−03

9.11E−05

1.90E−04

1.23E−03

BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_C

7.90E−03

    

BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D

3.16E−13

    

CEBALLOS_TARGETS_OF_TP53_AND_MYC_UP

9.92E−04

    

HALLMARK_P53_PATHWAY

6.25E−34

 

1.45E−15

1.71E−16

1.62E−04

INGA_TP53_TARGETS

2.45E−04

 

3.49E−06

3.64E−08

 

KANNAN_TP53_TARGETS_DN

  

9.50E−03

  

KANNAN_TP53_TARGETS_UP

5.37E−08

 

6.10E−03

 

1.35E−03

KEGG_P53_SIGNALING_PATHWAY

7.91E−09

 

8.69E−09

2.15E−13

 

MARTINEZ_RB1_AND_TP53_TARGETS_DN

1.48E−26

 

5.89E−08

 

8.07E−09

MARTINEZ_RB1_AND_TP53_TARGETS_UP

4.21E−21

 

2.07E−06

  

MARTINEZ_TP53_TARGETS_DN

5.70E−26

 

7.78E−06

 

1.78E−07

MARTINEZ_TP53_TARGETS_UP

6.53E−23

 

1.27E−08

  

MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN

1.47E−03

    

ONGUSAHA_TP53_TARGETS

6.43E−07

 

1.94E−14

5.42E−11

 

P53_DN.V1_DN

2.76E−04

 

1.05E−06

4.83E−03

2.73E−03

P53_DN.V1_UP

2.38E−10

   

2.44E−05

P53_DN.V2_DN

1.21E−03

 

1.28E−05

  

PEREZ_TP53_AND_TP63_TARGETS

7.06E−18

   

1.60E−04

PEREZ_TP53_TARGETS

1.59E−50

7.54E−03

4.75E−04

 

1.17E−03

PID_P53_DOWNSTREAM_PATHWAY

5.42E−11

 

3.99E−10

4.07E−06

3.59E−03

PID_P53_REGULATION_PATHWAY

4.17E−11

    

REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE

1.18E−03

    

SCHAVOLT_TARGETS_OF_TP53_AND_TP63

1.63E−04

 

5.86E−03

7.62E−04

 

SCIAN_INVERSED_TARGETS_OF_TP53_AND_TP73_DN

3.25E−07

    

STAMBOLSKY_TARGETS_OF_MUTATED_TP53_UP

6.50E−07

    

TANG_SENESCENCE_TP53_TARGETS_UP

   

2.70E−03

 

V$P53_02

4.24E−22

  

9.72E−03

9.11E−03

V$P53_DECAMER_Q2

2.59E−13

    

WU_APOPTOSIS_BY_CDKN1A_VIA_TP53

    

1.71E−04

  1. Abbreviations: CMV, cytomegalovirus; GSEA, gene set enrichment analysis; hNPC, human neural progenitors cell; MSigDB, Molecular Signature Database; ZIKV, Zika virus
  2. The table reports the significant (P<0.01) corrected P-values for the overlaps between the indicated GSEA data sets and the genes upregulated in ZIKV-infected hNPCs (ZIKV), CMV-infected hNPCs, CitK−/− P4 cerebellum, Magoh+/− E10.5 neocortex and Elp3−/− E13.5 brain. The corresponding gene lists are reported in Supplementary Table S1
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