Figure 8
Schematic illustrating the possible mechanisms of neuroprotective role of SIRT1 in EBI after SAH. As illustrated, SAH insults cause an increase in SIRT1 expression in neurons, leading to ac-FoxO, ac-NF-кB and ac-p53 deacetylation, which prevent the EBI. Inhibition of SIRT1 by sirtinol will block the signal transduction to induce neural cell death, eventually aggravate EBI following SAH. In contrast, activation SITR1 by activator 3 will stimulate the signal transduction to prevent EBI. The red and black arrows indicate direct or indirect induction, while the red and black blocked lines indicate direct or indirect repression
