Figure 1 | Cell Death & Disease

Figure 1

From: Block of both TGF-β and IL-2 signaling impedes Neurophilin-1+ regulatory T cell and follicular regulatory T cell development

Figure 1

Multi-organ inflammation in Il2ra−/−Tg mice. (a) Survival curve of Il2ra−/−Tg (n=8), Il2ra−/− (n=8), Il2ra+/−Tg (n=8) and Il2ra+/− (n=8) mice. Cell counts of (b) spleen, (c) peripheral (axillary, inguinal and brachial) lymph nodes of Il2ra−/−Tg (n=12), Il2ra−/− (n=12), Il2ra+/−Tg (n=12) and Il2ra+/− (n=12) mice. (d) Naive T cell (CD44−CD62L+) percentage and (e) IFN-γ secreting ability of CD4+ and CD8+ T cells in pLN from Il2ra−/−Tg (n=5), Il2ra−/− (n=5), Il2ra+/−Tg (n=5) and Il2ra+/− (n=5) mice. (f) Serum concentration of IFN-γ, TNF-α, IL-4 and IL-17A of Il2ra−/−Tg (n=6), Il2ra−/− (n=6), Il2ra+/−Tg (n=6) and Il2ra+/− (n=6) mice. Data are shown in mean±S.E.M. *P<0.05, **P<0.01, ***P<0.001. (Student’s t test)

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