Figure 1 | Cell Death & Disease

Figure 1

From: The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression

Figure 1

High expression of ATF1 promotes tumorigenesis in NPC. (a) Western blot assay to show the expression of ATF1 in various nasopharyngeal cells. (b) Colony formation assay showed the cell colony formation ability of NP69 cells with ATF1 overexpression. (c) Colony formation assay showed the cell colony formation ability of CNE1 cells with ATF1 overexpression. (d) Colony formation assay showed the cell colony formation ability of CNE2 cells with ATF1 knockdown. (e) Representative IHC staining of pATF1-Ser63 in NPC tissues and normal or reactive nasopharyngeal mucosal tissues. Scale bars, 50 μm. (f) Correlation between nasopharyngeal tissues with pATF1-Ser63 levels. (g) The mRNA expression of ATF1 is not statistically different between NPC and non-tumor tissues in a GEO data set. 'shNC' stands for the negative control of shRNA. *P<0.05

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