Figure 6
From: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light
Ccr2 knockout alleviates the activation of NLRP3 inflammasomes in blue light-induced retinopathy by the impairment of microglial recruitment. NLRP3 immunoactivity (green) was detected co-located with microglia (red) in WT+BLE mice after 1 month and 3 months. Cell nuclei (blue) were counterstained with DAPI. The fluorescent photomicrographs indicated that more NLRP3 was found co-localized with Iba1 (arrow) in WT+BLE mice retina after 1 month and 3 months compared with that in WT Ctrl and Ccr2−/−+BLE mice retinas after 3 months
